2: A STAT5-bound super-enhancer regulates expression of the Il2ra gene. It binds IL-2 with low affinity (K d 1.4 × 10 −8 M), but does not signal. IL-2 RECEPTOR STRUCTURE AND FUNCTION 31 Immunoprecipitations with anti-Tac performed under reducing conditions re-vealed that the IL-2 receptor was a 50000 dalton glycoprotein on HUT-102B2 cells but a 55000 dalton glycoprotein on normal activated T cells (Leonard 1982, 1983, 1985a, Wano et al. Krönke M, Leonard J, Depper M, Greene W. The gene encoding the human Interleukin 2 (IL-2) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. These findings support the principal role of IL-2R to deliver IL-2 to the signaling complex and act as regulator of signal transduction. Hum Cell. Under nonreducing conditions, the receptor Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. 1994 Mar;7(1):1-5. the IL-2 structure in response to receptor binding. Fig. Original Article Interleukin-2 and the IL-2 Receptor: New Insight Into Structure and Function William A Kuziel, Ph.D., 1 Warner C Greene, M.D., Ph.D. * 2 1 Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina, U.S.A. Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center Durham North Carolina … Structurally, IL-2Rα is related to IL-15Rα but contains an additional sushi domain that is connected to the first sushi domain by a linker region. The IL-2 receptor complex: its structure, function, and target genes. Fig. 1. IL-2 regulates growth and differentiation of various types of cells in the immune system via its interaction with IL-2 receptor (IL-2R). [Article in Japanese] Sugamura K(1). The IL-2R α-chain (Tac, CD25 or p55) is not a member of the haematopoietic receptor superfamily, but has two domains with homology to the complement control protein. The important role of this receptor in normal T-cell growth is well established and its potential participation in B-cell growth and differentiation appreciated. The IL-2 receptor protein, multiple receptor mRNAs, and a single structural gene have now been identified. Fig. The IL-2Rα is a specific receptor for IL-2 whilst IL-15Rα is bound by IL-15. The structure of the IL-2 signaling complex shows that IL-2 mainly interacts with the first sushi domain. 1984). Author information: (1)Department of Bacteriology, Tohoku University School of Medicine, Sendai, Japan. Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system.It is a 15.5–16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". [Structure and function of IL-2 receptor subunits]. The IL-2 receptor is also a complex of three chains 20. Minami Y., Kono T., Miyazaki T., Taniguchi T. Proliferation of T lymphocytes is triggered by the interaction of IL-2 with its specific receptor following T lymphocyte activation. 1: IL-2–IL-2 receptor structure and gene regulation. Structure and function of the human interleukin 2 receptor gene.