Bone pain, patholog- Address for correspondence and reprints: Dr. John A. Kanis, WHO Collaborating Centre for Metabolic Bone Diseases, Department of Hu- man Metabolism & Clinical Biochemistry, University of Sheffield Med- ical School, Beech Hill Road, Sheffield S10 2RX, UK. Zu den Prostaglandinen zählen im Einzelnen: Prostaglandin D2; Prostaglandin E2 (10). If you have a serious allergic response to one NSAID then you’re likely to have a similar response to a different NSAID so you should avoid all NSAIDs. 4.8 out of 5 stars. Prostaglandins (PG) Ez, EI, and Fz, was a kind gift from Dr. John Pike (Upjohn Co., Kalamazoo, M[). Community See All. glans = Eichel], Abk.PG, E prostaglandins, Gewebshormone verschiedener Struktur und Funktion, die sich von hochungesättigten C 20-Fettsäuren herleiten (meist Arachidonsäure-Abkömmlinge; siehe Abb. Dr. Josh Axe, DC, DNM, CNS, is a doctor of chiropractic, certified doctor of natural medicine and cl... See More. Simply put, they work by blocking the body’s production of chemicals known as prostaglandins that cause inflammation and pain. Doctor in Burton, Michigan. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Yes, aspirin and ibuprofen are some of the most common over-the-counter, nonprescription NSAIDs. Received for publication July 20, 2008; accepted for publication September 30, 2008. Die Dr. Axe-Stiftung hilft notleidenden Tieren, indem sie Patenschaften für einzelne Tiere übernimmt. Dr. Axe-Stiftung. I% of ethanol less than or equal to 0.01% did not affect the parameters measured. Das könnte Sie auch interessieren. Artikel wurde erstellt von: Dr. med. About See All. Das chemische Grundgerüst der Prostaglandine (PG) ist die … Note that the numbers in parentheses (1, 2, etc.) Public Figure. Arachidonsäure wird durch die Phospholipase A2 aus Membranlipiden freigesetzt. 30 Gluten-Free Recipes & detox juicing guide. Dr. rer. Page Transparency See More. Mit dem Prostaglandin- Analogon Latanoprost gibt es ein neuartiges Wirkprinzip zur Behandlung des Offenwinkelglaukoms. For these individuals, the dangers of NSAIDs can include experiencing a scary shortness of breath. 2,786,243 people follow this. Gastrointestinal side effects are the most common dangerous threat to chronic NSAID users. This was after I had talked to three of their personnell. Doctors have been concerned for some time that NSAIDs might play a role in heart failure since they cause consumers to retain sodium. In 1828, the willow tree bark’s active pain-fighting ingredient, salicin, was isolated. The dangers of NSAIDs are well-known yet often ignored, but now new research is making NSAID use even more questionable. : +49 228 - 24 12 18 Fax: +49 228 - 24 20 98 1 info@axe-stiftung.de Im Vergleich zu anderen Webseiten ist vielleicht nicht alles so perfekt, aber wir gehen persönlich auf alle Kritikpunkte ein und versuchen die Seite stets zu verbessern. Benefits & Dangers of IGF-1: Weight-Loss Promoter or Cancer Causer? or. Prostaglandine [von griech. Is Tylenol an NSAID? In women, prostaglandins assist in regulating the reproductive system. Forgot account? Useful. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Studies have shown the more prostaglandin inflammation you have, the worse your menstrual cramps can be, which is known as dysmenorrhea. Die Dr. Axe-Stiftung fördert Kunst und Kultur durch die Unterhaltung ihres Kunstkabinetts auf dem Hasenberghof in Kronenburg (Eifel). Zugleich hat der Stoff eine blutgerinnungshemmende Wirkung. Seit dem Jahre 2011 unterhält die Dr. Axe-Stiftung in Kronenburg, oberhalb des historischen Ortskerns, mit dem "Hasenberghof" eine Hofanlage, in der Tierschutzprojekte umgesetzt werden. Create New Account. Musculoskeletal pain is pain that affects the muscles, ligaments, tendons and bones. Community See All. November 1991 ; Andrologie 1(2):51-52; DOI: 10.1007/BF03034167. Then in 1897, aspirin (acetylsalicylic acid) was developed to improve the palatability of the painkiller for consumers. If you’ve been dealing with ongoing gastrointestinal (GI) issues — diarrhea, nausea, ... 5 Key Dangers of NSAIDs + Other Common Side Effects, White Willow Bark: The Natural Pain Reliever that Works Like Aspirin, 8 ‘You Won’t Believe It’ Natural Painkillers. What happens if my levels of prostaglandins are too high? Prostaglandins don't last long—they carry out their function, and then the body breaks them down. Es wird durch die Prostaglandin-E-Synthase aus Prostaglandin H 2 synthetisiert. Tylenol and other forms of acetaminophen can also ease pain and reduce fevers, but they do nothing for inflammation. I highly recommend opting for natural painkillers over NSAIDs when you can —such as adding wasabi in your diet since it’s a spicy food with natural painkilling properties. 1), im Tierreich generell und in nahezu allen Geweben verbreitet und vor kurzem auch in Pflanzen gefunden worden sind. Now, research just published in the British Medical Journal finds that NSAIDs increase the risk of heart failure by an alarming 19 percent. Page Transparency See More. What are NSAIDs? The prostaglandins (PG) are a group of physiologically active lipid compounds called eicosanoids having diverse hormone-like effects in animals.Prostaglandins have been found in almost every tissue in humans and other animals. In the 1960s, indomethacin (1964) and ibuprofen (1969) were some of the first non-aspirin NSAIDs. Authors: Maurizio Nordio. In fact, most painkillers on the market today are NSAIDs. 1 Definition. Arzt | Ärztin. Vielfältige Möglichkeiten als außerschulischer Lernort für Kindergarten- und Grundschulkinder bietet der Hasenberghof der Dr. Axe-Stiftung in Dahlem-Kronenburg (Eifel). Many drugs used for inflammation and pain contain steroids, which have questionable side effects of their own. The use of prostaglandins in obstetrics has undergone a rapid evolution since their discovery in the early 1970s. It doesn’t stop at foods, either. Das außergewöhnliche Domizil der Bilder wurde vom Stifter selbst ausgewählt. For instance, they may raise the risk of heart failure by nearly 20 percent. Fettsäuren durch Ringbildung und Einführung eines Sauerstoffmoleküls Prostaglandine gebildet. 4.8. I told them to have Dr. Josh Axe call me , They replied they did not know him.. (2). NSAIDs, aka nonsteroidal anti-inflammatory drugs, are one of the most commonly used pain relievers in the world today. Die Dr. Axe-Stiftung verfolgt ein breites Spektrum gemeinnütziger Zwecke. Related: White Willow Bark: The Natural Pain Reliever that Works Like Aspirin. Other common side effects and dangers of NSAIDs include: It’s estimated that every single day in this country more than 30 million Americans take NSAIDs for common pain and inflammation issues like headaches. 2,784,136 people follow this. COX-1 is present in most tissues, including the stomach lining. Hypoxic vasodilation is at least in part dependent on endothelial generation of prostaglandins. Dr.Ducks Ax Wax. Eat to Beat Disease: How to Eat for Optimal Health . (9), There are also specific dangers of NSAIDs for the younger population. (17). Prostaglandine haben stets Wechselwirkungen mit Prostaglandin-hemmenden Arzneistoffen. Facebook is showing information to help you better understand the purpose of a Page. Es wird im Arachidonsäure-Stoffwechsel aus Prostaglandin H2 gebildet. Community See All. NSAIDs is an acronym that stands for nonsteroidal anti-inflammatory drugs. Als Ausgangsprodukte für ihre Synthese dienen verschiedene Fettsäuren. Naiba Nabieva. Once blood clots are no longer needed and the injury begins to heal, another prostaglandin will stimulate the changes that allow the clots to dissipate and the blood vessel wall to relax. Sie sind hier: Startseite Laborwerte Prostaglandine. Dr. Josh Axe, DC, DNM, CNS, is a doctor of chiropractic, certified doctor of natural medicine and cl... See More. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Overall, the study found that seven traditional NSAIDs and two COX-2 inhibitors in particular led to an increased risk of heart failure. siehe Hauptartikel: Prostaglandinsynthese. Strukturformel der Prostansäure . (8). Indomethacin or ASA was diluted to the required … Außerdem ist dort ein öffentlich zugängliches Kunstkabinett untergebracht, in dem in wechselnden Ausstellungen Gemälde der "Düsseldorfer Malerschule" präsentiert werden. Willkommen bei "Dr. Axe" Hier finden Sie Informationen über das Bonner Traditionsunternehmen Dr. Hans Günther Axe Assekuranz Versicherungsmakler GmbH - kurz auch gerne Dr. Axe oder einfach AXEKURANZ genannt - sowie weiterführend über die Dr. Axe - Stiftung sowie den Unternehmensgründer und Stifter Dr. Hans Günther Axe. Note that the numbers in parentheses (1, 2, etc.) These OTC varieties will come in significantly lower doses than the prescription versions but are still quite powerful. A proper balance of Omega-3 and Omega-6 is important for maintaining health because they compete for the same enzymes for conversion. Complete avoidance of nonsteroidal anti-inflammatory drugs is recommended for most people with chronic kidney disease. Dr. Axe on Facebook Dr. Axe on Instagram Dr. Axe on Google Plus Dr. Axe on Youtube Dr. Axe on Pintrest Dr. Axe on RSS Dr. Axe on Instareads. It also includes possible threats to your esophagus and small intestine. Community See All. Prostaglandine sind ungesättigte Carbonsäuren, die aus 20 Kohlenstoffatomen, einschließlich eines geschlossenen 5er-Rings, bestehen. (11) NSAIDs are also the most commonly prescribed anti-inflammatory medicine for management of inflammatory conditions like arthritis. Prostaglandin E1 (Strukturformel) (PubChem) Weibliche sexuelle Dysfunktion: Warten auf Libido (DocCheck News) Klicke hier, um einen neuen Artikel im DocCheck Flexikon anzulegen. Es handelt sich meist um die Übernahme der Kosten medizinischer Behandlungen für sonst herrenlose Tiere aus Tierheimen oder Pflegestellen. The anti-inflammatory action of NSAIDs is mainly due to inhibition of COX-2, and their unwanted side effects (like bleeding ulcers) are largely due to inhibition of COX-1. Sie haben eine wichtige Funktion beim Schutz des Magens vor der Magensäure und bei der Durchblutung der Niere. Dr. Josh Axe, DC, DNM, CNS, is a doctor of chiropractic, certified doctor of natural medicine and cl... See More. Dr. Grog. For an asthma sufferer, the risk of experiencing serious allergic reaction to NSAIDs is even higher. Rice Water for Hair & Skin: Does It Really Work? (5). You can easily obtain over-the-counter NSAIDs without a doctor’s prescription. Indeed, a much stronger case can be made for the role of prostaglandins i … The role of prostaglandins in labor and delivery Clin Perinatol. Dr. Axe on Facebook 22 Dr. Axe on Twitter 0 Dr. Axe on Instagram Dr. Axe on Google Plus Dr. Axe on Youtube Dr. Axe on Pintrest 0 Share on Email Print Article 22 . Sofort lieferbar. Public Figure. draxe.com. Facebook is showing information to help you better understand the purpose of a Page. Anmeldeformular zur Fortbildung. Written by qualified journalists, expert guest authors or Dr. Axe himself, each piece is based on studies and always fact-checked. Synonyme: prostaglandin inhibitors. or. Correspondence to: Dr Jacques J. Tremblay, Reproduction, Perinatal, and Child Health, CHUQ Research Centre, CHUL Room T1-49, 2705 Laurier Blvd, Quebec City, QC Canada G1V 4G2 (e-mail: Jacques-J.Tremblay@crchul.ulaval.ca). Das katalysierende Enzym ist die Prostaglandin-D2-Synthase (PGDS), welche in zwei Isoformen vorkommt: 1996; accepted October 1, 1996. time for which the activity was performed were evaluated. Prostaglandin D2, kurz PGD2, ist ein Gewebshormon aus der Klasse der Prostaglandine.. 2 Biochemie. Als Ausgangsprodukte für ihre Synthese dienen verschiedene Fettsäuren. That helps limit their activity, which is a good thing. Contact Dr. Axe on Messenger. Auf dem Gnadenhof des Hasenberghofs leben Haustiere und Nutztiere in artgerechter Haltung bis zu ihrem natürlichen Tod. Endothelium from large arteries, veins, and the microcirculation can synthesize prostaglandins. Prostaglandine werden vom Körper gebildet und haben vielfältige Wirkungen, ... Dr-Gumpert.de ist ein Projekt, das mit viel Engagement vom Dr-Gumpert.de Team betrieben wird. (13), Is aspirin an NSAID? Prostaglandine sind chemische Verbindungen aus der Gruppe der Eicosanoide. Letzte Autoren des Artikels: Dr. Frank Antwerpes. The gastrointestinal concerns like bleeding ulcers are scary enough, but you also have some life-threatening heart health concerns. Prostaglandin synthesis is also found in vascular smooth muscle. Many new types of NSAIDs have been introduced to consumers since then, like diclofenac in 1974 and naproxen in 1976. (12). Yes, it is quite serious because when ... Hyperthyroidism vs. Hypothyroidism: How to Tell the Difference, How to Control Prostaglandin Production: Do’s & Don’ts, Hyperparathyroidism Causes and Symptoms (Plus, 6 Natural Remedies), Menopause Symptoms to Watch For and Ways to Relieve Them, Thyroid Nodules: 7 Natural Ways to Manage Symptoms of Thyroid Disease, What Is Epinephrine? Synonym: PGF 2α. The good news is there are natural ways to get rid of a fever. Prostaglandins play a key role in inflammation by contributing to the development of redness, swelling, heat, and pain. About See All. DOI: 10.2164/jandrol.108.006387 … What Prostaglandins Do . Informationen zum Versand . (14). 3,835 people like this. While pain medication has its uses, the dangers of NSAIDs are too great to ignore. ical fracture, and hypercalcemia account collectively for a large part of morbidity and some of the mortality … These were dissolved in ethanol at a concentration of 50 mg/ml and diluted at least 10,000-fold in PBS prior to use. When it comes to dangers of NSAIDS, more specifically heart health concerns, the American Heart Association recommends that all NSAIDs should be used at their lowest effective doses. 2,765,361 people like this. Concentrations of DMSO less than 0. Clinically detectable edema occurs in less than 5 percent of patients. Role de la glande pineale dans la regulation de l’axe hypothalamo-hypophyso-testiculaire. prostates = Vorsteher, latein. Fast-forward to today, and NSAIDs are some of the most common pain relievers in the entire world. : 0228 - 24 12 18, Email: info@axe-stiftung.de. Dr. Axe encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Facebook is showing information to help you better understand the purpose of a Page. However, it wasn’t until 1874 that the industrial production of salicylic acid began. Substanzen, die die Bildung von Prostaglandinen hemmen u. somit deren proinflammatorische Wirkungen aufheben. Anyone can develop a stomach ulcer while taking NSAIDs. 55 Martin and colleagues 180 have shown that hypoxia increases prostacyclin release from vascular endothelium. Neben der Unterstützung von Opfern von Gewaltverbrechen, der Förderung der Altenhilfe, Kunst und Kultur sowie des Tierschutzes gewährt die Dr. Axe-Stiftung finanzielle Beihilfen an Krankenhäuser zur Anschaffung neuer Instrumente oder Geräte oder medizinischer Einrichtungen und Ausstattungen. I always suggest natural painkillers over NSAIDs any day. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Mit Prostaglandin E1 (PGE1) wurde gewissermaßen ein neues Kapitel in der medikamentösen Therapie der AVK aufgeschlagen. If NSAID isn’t ringing a bell, you might be more familiar with generic names like ibuprofen or name brand NSAIDs like Aleve®, Motrin® and Advil®. They’re most commonly used for pain and inflammation reduction, but how do they work exactly? See more of Creekwood Dental with Dr. Qamar on Facebook. Prostaglandine werden vom Körper gebildet und haben vielfältige Wirkungen, ... Dr-Gumpert.de ist ein Projekt, das mit viel Engagement vom Dr-Gumpert.de Team betrieben wird. Our team aims to be not only thorough with its research, but also objective and unbiased. (3) I’ve talked before about ibuprofen overdose, and now I want to tell you all about NSAIDs in general, including how exactly they’re effective, why the dangers of NSAIDs really can’t be taken lightly and what are some safer, natural alternatives. A Surprising Factor in Celiac Disease, Candida Diet: The Foods & Supplements to Eat (and Avoid) to Treat Candida, 9 Candida Symptoms and 3 Steps to Treat Them, What Your Tongue Appearance Means for Your Health, According to Chinese Medicine, How to Stop Diarrhea: Causes, Risk Factors and Home Remedies, How to Get Rid of Herpes Symptoms Naturally, Aspirin compounds (such as Bayer®, Bufferin® and Excedrin®). This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. A Dr. Grog zenekar hivatalos Facebook oldala. You might want to check those out and give them a try before popping any NSAID pills. Aspirin is the only NSAID that inhibits the blood clotting for a prolonged period of time (four to seven days), which is why many doctors recommend it for preventing blood clots that cause heart attacks and strokes. 3 Substanzen. Try Prime EN Hello, Sign in Account & Lists Sign in Account & Lists Returns & Orders Try Prime Cart. Prostaglandin hormones are made by nearly every cell in the body. Besonders reich sind sie im Sperma vertreten. An icon used to represent a menu that can be toggled by interacting with this icon. Additionally they were so rude, I do not see how Dr. Axe and Jordan could keep them on staff.The product does not do what Dr. Axe and Jordan Promised. Seit dem Jahre 2011 unterhält die Dr. Axe-Stiftung in Kronenburg, oberhalb des historischen Ortskerns, mit dem "Hasenberghof" eine Hofanlage, in der Tierschutzprojekte umgesetzt werden. Dr. Axe > Nutrition. Sie stammt entweder aus der Nahrung oder wird durch Kettenverlängerung aus essentiellen Fettsäuren (z.B. Über uns . 4,222 people follow this. This large study specifically looked at the risk of hospital admission for heart failure and the use of 27 individual NSAIDs. You should definitely talk to your doctor before using NSAIDs if you’re over 60, taking prescription blood thinners, or have stomach ulcers or other bleeding problems. Außerdem ist dort ein öffentlich zugängliches Kunstkabinett untergebracht, in dem in wechselnden Ausstellungen Gemälde der "Düsseldorfer Malerschule" präsentiert werden. Es wird seit 1.1.2006 von der Herstellerfirma Pfizer in Deutschland nicht mehr vertrieben und steht nur noch als Reimport-Medikament zur Verfügung. The researchers found that current use of any NSAID was found to be associated with a 19 percent increase of risk of hospital admission for heart failure. But I hope you look to utilize all of the natural pain remedies and tools out there so you can truly get to the root of your problem and give yourself some real and lasting relief. More specifically, they block the cyclo-oxygenase (COX) enzymes, which in turn inhibits production of prostaglandins. According to gastroenterologist Byron Cryer, MD, a spokesperson for the American Gastroenterological Association, more than half of all bleeding ulcers are caused by NSAIDs. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Public Figure. The use of aspirin by children and teenagers with chickenpox or the flu has been associated with the development of Reye’s syndrome. That sudden pounding heartbeat. … Address reprint requests to: Dr. Martha L. Slattery, Department of Oncological Sciences/PHS, Huntsman Cancer Institute, 546 Chipeta Way, Salt Lake City, UT 84108. This syndrome is rare yet serious. Dipl.-Biol. First, it’s important to remember that unless a fever is very high, it’s generally harmless and a good sign that your immune system is working properly. No, Tylenol is not a member of the NSAID family. Tylenol® is the brand name for an over-the-counter form of acetaminophen. Tune in every Tuesday for new episodes and make sure to subscribe and leave a review! Page Transparency See More. Facebook is showing information to help you better understand the purpose of a Page. When diclofenac, indomethacin, piroxicam, etoricoxib and rofecoxib were taken at “very high doses” (meaning two or more daily doses), the risk for heart failure doubled. 2,765,004 people like this. Sie wirken im menschlichen und höheren tierischen Organismus als Gewebshormone und kommen mit verschiedener Struktur und Funktion überall im Organismus vor. 1,426 people follow this. Yes, that’s right — anyone. Five NSAIDs in particular were linked to significant increased risk of heart failure admission: The two COX-2 inhibitors are etoricoxib and rofecoxib, which are both currently not approved for use in the United States. (16). But even if it’s nothing to get overly worried about, most people with a fever just can’t want for it to break. Not Now. Diets . They might effectively and temporarily decrease pain, but according to analysis of almost 10 million patient medical records, that dangers of NSAIDs are pretty clear. Es handelt sich um ein Prostaglandin-E1-Derivat, das in der Geburtshilfe weltweit eingesetzt wird, für die Anwendung in der Schwangerschaft aber nicht zugelassen, sondern laut Firmenangabe kontraindiziert ist. Mai 2019. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. draxe.com. When you have pain, it’s also very smart to avoid pro-inflammatory and pro-pain items like sugar, alcohol, caffeine and trans fats. 8.4 keV; it was kindly provided by Dr. P. Pychlau, GmbH, Freiburg (personal communication). Gastrointestinal Damage, Ulcers and Internal Bleeding, NSAIDs all share the same most prevalent side effect — damage to the gastrointestinal tract, which doesn’t just mean your stomach. Dr. Axe-Stiftung Adenauerallee 133 53113 Bonn Tel. Share. Community See All. are clickable links to these studies. Public Figure. Prostaglandins play numerous roles in the human body, some negative and some positive. However, the decreased post-thyroidectomy … Prostaglandin E1 bindet an Rezeptoren in der Muskelschicht der Blutgefäße. Artikel schreiben. For most healthy people, occasionally taking an over-the-counter NSAID might not cause any noticeable problems, but frequent or chronic use is really proving itself to be lethal. Acetaminophen products are known for being easier on the stomach than NSAIDs, but they can damage the liver, among other serious side effects. It can cause liver as well as brain damage, and sometimes even fatal liver disease or permanent brain damage. Nonsteroidal is a term that was first used in 1960 to separate NSAID drugs from steroid treatment related to medical tragedies. That risk increases with the amount of NSAIDs a person takes, says study author Andrea Arfe, a Ph.D student at the University of Milano-Bicocca, in Italy. According to the American College of Gastroenterology, most ulcers caused by NSAIDs heal once you stop taking the drug so the sooner you stop taking NSAIDs the better. Veranstaltungsort: Hasenberghof der Dr. Axe-Stiftung Gerichtsstraße 12, 53949 Kronenburg/Dahlem . 181 check-ins. Thus, the components of physical activity that are associated with reduced risk of colon cancer and applicable … (7) Edema is a medical term for swelling caused by excess fluid being trapped in your body’s tissues. {These authors contributed equally to this work. I told her she best be looking for a new job. Maximal Standardized Uptake Value on FDG-PET Is Correlated With Cyclooxygenase-2 Expression in Patients With Lung Adenocarcinoma Katsuhiko Shimizu, MD, PhD, Yuji Hirami, MD, PhD, Shinsuke Saisho, MD, Takuro Yukawa, MD, Ai Maeda, MD, Koichiro Yasuda, MD, and Masao Nakata, MD, PhD Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan Dr. Axe on Facebook 11 Dr. Axe on Twitter 0 Dr. Axe on Instagram Dr. Axe on Google Plus Dr. Axe on Youtube Dr. Axe on Pintrest 72 Share on Email Print Article 83 . About See All. Page Transparency See More. Most people are familiar with nonprescription over-the-counter NSAIDs, such as aspirin and ibuprofen. 1080 Creekwood Trl (1,750.17 mi) Burton, MI, MI 48509. While all … NSAIDs also encourage the body to hold on to sodium which can lead to varying degrees of reduction in kidney function. Peptic ulcers form because the action of NSAIDs block the COX-1 enzyme from protecting the stomach lining. Received May 5. Sweaty palms. COX-2 is the enzyme primarily present at sites of inflammation.