This document has been annotated to highlight those areas which are covered by the latest clinical guidance from the National Institute for Health and Clinical Excellence (NICE) [NICE Clinical Guideline 134, December 2011]. Definition. There are three forms of hypersensitivity pneumonitis acute, subacute, and chronic that are defined by how severe the symptoms are and how quickly they develop. Drug hypersensitivity is an immune-mediated reaction to a drug. Pavlos R et al. Start febuxostat after the acute attack has resolved. Treatment of acute or subacute hypersensitivity pneumonitis is with corticosteroids, usually prednisone 60 mg orally once a day for 1 to 2 weeks, then tapered over the next 2 to 4 weeks to 20 mg once a day, followed by weekly decrements of 2.5 mg until the drug is stopped. J Allergy Clin Immunol. Hypersensitivity skin reactions include urticaria , erythema multiforme , Staphylococcal scalded skin syndrome, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome , and toxic epidermal necrolysis . • Mainly children and young adults • Commoner in females • Incidence seems to be increasing. Choice of long‐term maintenance AEDs should take into consideration the crossreactivity among AEDs that share an arene oxide metabolite. What causes anaphylaxis? Treatment for the type III hypersensitivity reaction to HSA included administration of diphenhydramine and glucocorticoids. METHODS: Reaction frequency and severity, dose, phase of treatment, and time between infusion initiation and reaction were collected on patients identified as having an IV PEG-asparaginase hypersensitivity reaction while undergoing acute lymphoblastic leukemia treatment. The best advice is to avoid the offending antigen. Perform liver function tests (LFTs) before starting febuxostat treatment, as mild liver test abnormalities have been observed. Oncology nurses have experience in hypersensitivity reactions with different chemotherapy agents, but with the increased use of monoclonal antibody therapy in the treatment of various cancers, knowledge of specific risk and management of reactions with these therapies is important. Hypersensitivity skin reactions are due to an exaggerated immune system reaction towards an antigen, and some reactions can be life-threatening. However, physicians should be aware of these potential side effects to determine whether the reactions constitute true allergies and how to proceed with growth hormone therapy. Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, is the result of non-IgE mediated immunological inflammation. Hypersensitivity reactions to chemotherapy agents are defined as unexpected reactions with signs and symptoms not consistent with known toxicity of these drugs. Monitor patients for worsening of these symptoms while on treatment. Both dogs were humanely euthanized. These reactions range from mild to life-threatening and are difficult to predict. 2003;68(9):1781-90. The mild hypersensitivity reaction (grade 1 or 2) usually responds to discontinuation of oxaliplatin and supportive treatment with antihistamine agents and steroid. It is characterised by rapidly If acute intolerance syndrome is suspected, promptly discontinue treatment with CANASA. Symptoms include flushing, nausea, difficulty breathing, back pain, hypotension and tachycardia. It describes the recognition and treatment of an anaphylactic reaction including the delivery of drugs for treatment. Drugs & Therapeutics Committee_Guidelines for the Management of Systemic Ant-Cancer Treatment (SACT) Hypersensitivity Reactions (HRs)_V1.0_operational date Record: All HRs should be graded according to the CTCAE v5. This regimen relieves initial symptoms but does not appear to alter long-term outcome. Type II hypersensitivity reactions are referred to as cytotoxic, as they involve antibodies that are specific to particular tissues within the body and cause destruction of cells in these tissues (e.g., autoimmune hemolytic anemia , Goodpasture syndrome ). Once any acute inflammatory changes have resolved, the most frequent reaction observed with tattoos is an allergic sensitivity to one of its pigments. Arthus reaction is a type III hypersensitivity reaction involving IgG antibodies bound to foreign antigens in the blood. Eczematous hypersensitivity reactions. Symptoms range from mild to severe and include rash, anaphylaxis, and serum sickness. New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity.